TPH2 monoclonal antibody, clone CL2990
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human TPH2.
Immunogen
Recombinant protein corresponding to human TPH2.
Sequence
SITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLG
Host
Mouse
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Protein A purification
Isotype
IgG1
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:1000-1:2500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cerebral cortex with TPH2 monoclonal antibody, clone CL2990 (Cat # MAB15785) shows immunoreactivity in serotonergic fibers. -
Gene Info — TPH2
Entrez GeneID
121278Protein Accession#
Q8IWU9Gene Name
TPH2
Gene Alias
FLJ37295, MGC138871, MGC138872, NTPH
Gene Description
tryptophan hydroxylase 2
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq
Other Designations
neuronal tryptophan hydroxylase|tryptophan 5-monooxygenase 2
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Pathway
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Disease
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