DDC monoclonal antibody, clone CL2962
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Specifications
Product Description
Mouse monoclonal antibody raised against partial recombinant human DDC.
Immunogen
Recombinant protein corresponding to human DDC.
Epitope
This antibody binds to an epitope located within the peptide sequence MDWLGKMLEL as determined by overlapping synthetic peptides.
Sequence
LETVMMDWLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASA
Host
Mouse
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Protein A purification
Isotype
IgG1
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:1000-1:2500)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western Blot analysis of human kidney tissue lysate with DDC monoclonal antibody, clone CL2962 (Cat # MAB15780).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human substantia nigra with DDC monoclonal antibody, clone CL2962 (Cat # MAB15780) shows strong immunoreactivity in dopamine neurons. -
Gene Info — DDC
Entrez GeneID
1644Protein Accession#
P20711Gene Name
DDC
Gene Alias
AADC
Gene Description
dopa decarboxylase (aromatic L-amino acid decarboxylase)
Gene Ontology
HyperlinkGene Summary
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq
Other Designations
L-Dopa decarboxylase|aromatic L-amino acid decarboxylase
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Interactomes
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Pathways
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Diseases
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