NEFH monoclonal antibody, clone CL2671
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More Files
- More Functions
Western Blot (Tissue lysate)
Western Blot analysis of human cerebral cortex tissue lysate with NEFH monoclonal antibody, clone CL2671 (Cat # MAB15768).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cerebellum with NEFH monoclonal antibody, clone CL2671 (Cat # MAB15768) shows moderate immunoreactivity in Purkinje cells and neural fibers.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human NEFH.
Immunogen
Recombinant protein corresponding to human NEFH.
Epitope
This antibody binds to an epitope located within the peptide sequence ECRIGFGPIPFSLPE as determined by overlapping synthetic peptides.
Sequence
ECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEE
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG1
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:500-1:1000)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western Blot analysis of human cerebral cortex tissue lysate with NEFH monoclonal antibody, clone CL2671 (Cat # MAB15768).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cerebellum with NEFH monoclonal antibody, clone CL2671 (Cat # MAB15768) shows moderate immunoreactivity in Purkinje cells and neural fibers. -
Gene Info — NEFH
Entrez GeneID
4744Protein Accession#
P12036Gene Name
NEFH
Gene Alias
NFH
Gene Description
neurofilament, heavy polypeptide
Gene Ontology
HyperlinkGene Summary
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq
Other Designations
neurofilament triplet H protein|neurofilament, heavy polypeptide 200kDa
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Interactome
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Pathway
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Disease
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