HSP90B1 monoclonal antibody, clone CL2647
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot analysis of U-251 cell lysate with HSP90B1 monoclonal antibody, clone CL2647 (Cat # MAB15763).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human prostate with HSP90B1 monoclonal antibody, clone CL2647 (Cat # MAB15763) shows strong cytoplasmic immunoreactivity in glandular cells.
Immunofluorescence
Immunofluorescent staining of MCF7 cells with HSP90B1 monoclonal antibody, clone CL2647 (Cat # MAB15763) (Green) shows specific endoplasmic reticulum. Microtubule and nuclear probes are visualized in red and blue respectively (where available).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human HSP90B1.
Immunogen
Recombinant protein corresponding to human HSP90B1.
Epitope
This antibody binds to an epitope located within the peptide sequence EEEPEETAED as determined by overlapping synthetic peptides.
Sequence
SGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTA
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG2b
Recommend Usage
Immunofluorescence (1-4 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:5000-1:10000)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of U-251 cell lysate with HSP90B1 monoclonal antibody, clone CL2647 (Cat # MAB15763).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human prostate with HSP90B1 monoclonal antibody, clone CL2647 (Cat # MAB15763) shows strong cytoplasmic immunoreactivity in glandular cells.Immunofluorescence
Immunofluorescent staining of MCF7 cells with HSP90B1 monoclonal antibody, clone CL2647 (Cat # MAB15763) (Green) shows specific endoplasmic reticulum. Microtubule and nuclear probes are visualized in red and blue respectively (where available). -
Gene Info — HSP90B1
Entrez GeneID
7184Protein Accession#
P14625Gene Name
HSP90B1
Gene Alias
ECGP, GP96, GRP94, TRA1
Gene Description
heat shock protein 90kDa beta (Grp94), member 1
Omim ID
191175Gene Ontology
HyperlinkGene Summary
HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90B1 is an endoplasmic reticulum HSP90 protein. Other HSP90 proteins are found in cytosol (see HSP90AA1; MIM 140571) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM
Other Designations
Tumor rejection antigen-1 (gp96)|endothelial cell (HBMEC) glycoprotein|glucose regulated protein, 94 kDa|heat shock protein 90kDa beta, member 1|tumor rejection antigen (gp96) 1
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Interactome
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Pathway
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Disease
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