ABCD3 monoclonal antibody, clone CL2524
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human ABCD3.
Immunogen
Recombinant protein corresponding to human ABCD3.
Epitope
This antibody binds to an epitope located within the peptide sequence GVQVIPLIPGAGEII as determined by overlapping synthetic peptides.
Sequence
MVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVLICGP
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG1
Recommend Usage
Immunofluorescence (1-4 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human rectum with ABCD3 monoclonal antibody, clone CL2524 (Cat # MAB15753) shows strong granular cytoplasmic immunoreactivity in glandular cells.Immunofluorescence
Immunofluorescent staining of HeLa cells with ABCD3 monoclonal antibody, clone CL2524 (Cat # MAB15753) (Green) shows specific peroxisomes. Microtubule and nuclear probes are visualized in red and blue respectively (where available). -
Gene Info — ABCD3
Entrez GeneID
5825Protein Accession#
P28288Gene Name
ABCD3
Gene Alias
ABC43, PMP70, PXMP1
Gene Description
ATP-binding cassette, sub-family D (ALD), member 3
Omim ID
170995Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
ATP-binding cassette, sub-family D, member 3|OTTHUMP00000012428|Peroxisomal membrane protein-1 (70kD)|dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1))|peroxisomal membrane protein 1 (70kD, Zellweger syndrome)
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Interactome
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