ZYX monoclonal antibody, clone CL2502
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with ZYX monoclonal antibody, clone CL2502 (Cat # MAB15751) shows strong membranous and moderate cytoplasmic immunoreactivity in renal glomeruli and tubule.
Immunofluorescence
Immunofluorescent staining of HeLa cells with ZYX monoclonal antibody, clone CL2502 (Cat # MAB15751) (Green) shows distinct focal adhesion. Microtubule and nuclear probes are visualized in red and blue respectively (where available).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human ZYX.
Immunogen
Recombinant protein corresponding to human ZYX.
Epitope
This antibody binds to an epitope located within the peptide sequence APGPLTLKEVEELEQ as determined by overlapping synthetic peptides.
Sequence
PAPKFSPVTPKFTPVASKFSPGAPGGSGSQPNQKLGHPEALSAGTGSPQPPSFTYAQQREKPRVQEKQHPVPPPAQNQNQVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNE
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG2b
Recommend Usage
Immunofluorescence (1-4 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:5000-1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with ZYX monoclonal antibody, clone CL2502 (Cat # MAB15751) shows strong membranous and moderate cytoplasmic immunoreactivity in renal glomeruli and tubule.Immunofluorescence
Immunofluorescent staining of HeLa cells with ZYX monoclonal antibody, clone CL2502 (Cat # MAB15751) (Green) shows distinct focal adhesion. Microtubule and nuclear probes are visualized in red and blue respectively (where available). -
Gene Info — ZYX
Entrez GeneID
7791Protein Accession#
Q15942Gene Name
ZYX
Gene Alias
ESP-2, HED-2
Gene Description
zyxin
Omim ID
602002Gene Ontology
HyperlinkGene Summary
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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