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PDIA3 monoclonal antibody, clone CL2446

  • Catalog # : MAB15749
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant human PDIA3.
  • Immunogen:
  • Recombinant protein corresponding to human PDIA3.
  • Sequence:
  • PTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDK
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein A purification
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:5000-1:10000)
    Western Blot (1:500-1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Epitope:
  • This antibody binds to an epitope located within the peptide sequence PTLKIFRDGEEAGAY as determined by overlapping synthetic peptides.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western Blot analysis of U-251 MG cell lysate with PDIA3 monoclonal antibody, clone CL2446 (Cat # MAB15749).
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cerebellum with PDIA3 monoclonal antibody, clone CL2446 (Cat # MAB15749) shows cytoplasmic immunoreactivity in Purkinje cells.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 2923
  • Gene Name:
  • PDIA3
  • Gene Alias:
  • ER60,ERp57,ERp60,ERp61,GRP57,GRP58,HsT17083,P58,PI-PLC
  • Gene Description:
  • protein disulfide isomerase family A, member 3
  • Gene Summary:
  • This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq
  • Other Designations:
  • 58 kDa microsomal protein,OTTHUMP00000041709,endoplasmic reticulum P58,glucose regulated protein, 58kDa,phospholipase C-alpha,protein disulfide isomerase-associated 3,protein disulfide-isomerase A3
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