CARS monoclonal antibody, clone CL2302
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human CARS.
Immunogen
Recombinant protein corresponding to human CARS.
Epitope
This antibody binds to an epitope located within the peptide sequence RPNQALLENIALYLT as determined by overlapping synthetic peptides.
Sequence
SQCNLYMAARKAVRKRPNQALLENIALYLTHMLKIFGAVEEDSSLGFPVGGPGTSLSLEATVMPYLQVLSEFREGVRKIAREQKVPEILQLSDALRDNILPELGVRFEDHEGLPTVVKLVDRNTLLKEREEKRRVE
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG1
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:1000-1:2500)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of U-251 MG cell lysate with CARS monoclonal antibody, clone CL2302 (Cat # MAB15738).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast cancer with CARS monoclonal antibody, clone CL2302 (Cat # MAB15738) shows cytoplasmic immunoreactivity in tumor cells. -
Gene Info — CARS
Entrez GeneID
833Protein Accession#
A8MVQ3Gene Name
CARS
Gene Alias
CARS1, CYSRS, MGC:11246
Gene Description
cysteinyl-tRNA synthetase
Omim ID
123859Gene Ontology
HyperlinkGene Summary
This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
OTTHUMP00000012605|cysteine tRNA ligase 1, cytoplasmic|cysteine translase|cysteine-tRNA ligase
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Interactome
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Disease
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