SOX10 monoclonal antibody, clone CL4455
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast shows strong nuclear positivity in glandular cells.
Immunofluorescence
Immunofluorescence staining of WM-115 cell with antibody shows specific staining in the nucleoplasm in green. Microtubule- and nuclear probes are visualized in red and blue, respectively.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human SOX10.
Immunogen
Recombinant protein corresponding to human SOX10.
Sequence
PHYTDQPSTSQIAYTSLSLPHYGSAFPSISRPQFDYSDHQPSGPYYGHSG
Host
Mouse
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein A purification
Isotype
IgG1
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:2500-1:5000)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast shows strong nuclear positivity in glandular cells.Immunofluorescence
Immunofluorescence staining of WM-115 cell with antibody shows specific staining in the nucleoplasm in green. Microtubule- and nuclear probes are visualized in red and blue, respectively. -
Gene Info — SOX10
Entrez GeneID
6663Protein Accession#
P56693Gene Name
SOX10
Gene Alias
DOM, MGC15649, WS2E, WS4
Gene Description
SRY (sex determining region Y)-box 10
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. [provided by RefSeq
Other Designations
OTTHUMP00000028515|OTTHUMP00000195094|SRY-related HMG-box gene 10|dominant megacolon, mouse, human homolog of
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Interactome
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Disease
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