CD68 monoclonal antibody, clone CL1346
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More Files
- More Functions
Western Blot (Tissue lysate)
Western Blot analysis of human spleen tissue lysate with CD68 monoclonal antibody, clone CL1346 (Cat # MAB15679).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human tonsil with CD68 monoclonal antibody, clone CL1346 (Cat # MAB15679) shows strong immunoreactivity in a subset of lymphoid cells.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human CD68.
Immunogen
Recombinant protein corresponding to human CD68.
Epitope
This antibody binds to an epitope located within the peptide sequence SPTSKETIGDYTWTN as determined by overlapping synthetic peptides.
Sequence
SPTSKETIGDYTWTNGSQPCVHLQAQIQIRVMYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHLLLSFPYG
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG1
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:1000-1:2500)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western Blot analysis of human spleen tissue lysate with CD68 monoclonal antibody, clone CL1346 (Cat # MAB15679).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human tonsil with CD68 monoclonal antibody, clone CL1346 (Cat # MAB15679) shows strong immunoreactivity in a subset of lymphoid cells. -
Gene Info — CD68
Entrez GeneID
968Protein Accession#
P34810Gene Name
CD68
Gene Alias
DKFZp686M18236, GP110, SCARD1
Gene Description
CD68 molecule
Omim ID
153634Gene Ontology
HyperlinkGene Summary
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq
Other Designations
CD68 antigen|OTTHUMP00000135285|macrophage antigen CD68|macrosialin|scavenger receptor class D, member 1
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Interactome
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Pathway
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