ESR1 monoclonal antibody, clone CL1196
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot analysis of Lane 1: MCF-7 and Lane 2: SK-BR-3 cell lysates with ESR1 monoclonal antibody, clone CL1196 (Cat # MAB15674).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human endometrium with ESR1 monoclonal antibody, clone CL1196 (Cat # MAB15674) shows strong nuclear immunoreactivity in glandular cells.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human ESR1.
Immunogen
Recombinant protein corresponding to human ESR1.
Epitope
This antibody binds to an epitope located within the peptide sequence YTVREAGPPAFYRPN as determined by overlapping synthetic peptides.
Sequence
FGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTID
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG1
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:1000-1:2500)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of Lane 1: MCF-7 and Lane 2: SK-BR-3 cell lysates with ESR1 monoclonal antibody, clone CL1196 (Cat # MAB15674).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human endometrium with ESR1 monoclonal antibody, clone CL1196 (Cat # MAB15674) shows strong nuclear immunoreactivity in glandular cells. -
Gene Info — ESR1
Entrez GeneID
2099Protein Accession#
P03372Gene Name
ESR1
Gene Alias
DKFZp686N23123, ER, ESR, ESRA, Era, NR3A1
Gene Description
estrogen receptor 1
Gene Ontology
HyperlinkGene Summary
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq
Other Designations
OTTHUMP00000017718|OTTHUMP00000017719|estrogen receptor alpha
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Interactome
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Disease
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