PLA2R1 monoclonal antibody, clone CL0485
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: negative control (vector only transfected HEK293T cell lysate) and Lane 2: over-expression lysate (co-expressed with a C-terminal myc-DDK tag in mammalian HEK293T cells) with PLA2R1 monoclonal antibody, clone CL0485 (Cat # MAB15634).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with PLA2R1 monoclonal antibody, clone CL0485 (Cat # MAB15634) shows strong membranous immunoreactivity in renal glomeruli.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human PLA2R1.
Immunogen
Recombinant protein corresponding to human PLA2R1.
Epitope
This antibody binds to an epitope located within the peptide sequence VKNCEERLFYICKKA as determined by overlapping synthetic peptides.
Sequence
EEKTWHEALRSCQADNSALIDITSLAEVEFLVTLLGDENASETWIGLSSNKIPVSFEWSNDSSVIFTNWHTLEPHIFPNRSQLCVSAEQSEGHWKVKNCEERLFYICKKAGHVLSDAESGCQEGWERHGGFCYKID
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG1
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1:500)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: negative control (vector only transfected HEK293T cell lysate) and Lane 2: over-expression lysate (co-expressed with a C-terminal myc-DDK tag in mammalian HEK293T cells) with PLA2R1 monoclonal antibody, clone CL0485 (Cat # MAB15634).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with PLA2R1 monoclonal antibody, clone CL0485 (Cat # MAB15634) shows strong membranous immunoreactivity in renal glomeruli. -
Gene Info — PLA2R1
Entrez GeneID
22925Protein Accession#
Q13018Gene Name
PLA2R1
Gene Alias
CLEC13C, PLA2-R, PLA2G1R, PLA2IR, PLA2R
Gene Description
phospholipase A2 receptor 1, 180kDa
Omim ID
604939Gene Ontology
HyperlinkGene Summary
Secretory phospholipases A2 (PLA2s) have been purified from a variety of mammalian tissues as well as from insect and snake venoms. The prototype group I PLA2, the pancreatic PLA2 (PLA2G1B; MIM 172410), is involved in digestion, smooth muscle contraction, and cell proliferation. The prototype group II PLA2, the inflammatory-type PLA2 (PLA2G2A; MIM 172411), is involved in inflammatory conditions and is upregulated by proinflammatory cytokines like tumor necrosis factor (TNF; MIM 191160) and interleukin-1 (e.g., IL1B; MIM 147720). Differential toxicity of snake venom Pla2 appears to be linked to a variety of high-affinity receptors in different organs (Ancian et al., 1995 [PubMed 7721806]).[supplied by OMIM
Other Designations
phospholipase A2 receptor 1
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Interactome
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Disease
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