CA12 monoclonal antibody, clone CL0278
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More Files
- More Functions
Western Blot (Tissue lysate)
Western Blot analysis of human tonsil tissue lysate with CA12 monoclonal antibody, clone CL0278 (Cat # MAB15589).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with CA12 monoclonal antibody, clone CL0278 (Cat # MAB15589) shows strong membranous immunoreactivity in renal tubules, but not glomeruli.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human CA12.
Immunogen
Recombinant protein corresponding to human CA12.
Epitope
This antibody binds to an epitope located within the peptide sequence HLQHVKYKGQEAFVP as determined by overlapping synthetic peptides.
Sequence
TASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQ
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG2a
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:2500-1:5000)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western Blot analysis of human tonsil tissue lysate with CA12 monoclonal antibody, clone CL0278 (Cat # MAB15589).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with CA12 monoclonal antibody, clone CL0278 (Cat # MAB15589) shows strong membranous immunoreactivity in renal tubules, but not glomeruli. -
Gene Info — CA12
Entrez GeneID
771Protein Accession#
O43570Gene Name
CA12
Gene Alias
CAXII, FLJ20151, HsT18816
Gene Description
carbonic anhydrase XII
Omim ID
603263Gene Ontology
HyperlinkGene Summary
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq
Other Designations
carbonic dehydratase
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Interactome
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Pathway
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