FUS monoclonal antibody, clone CL0190
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot analysis of Lane 1: HeLa, Lane 2: A-431, Lane 3: MCF-7, Lane 4: U2-OS and Lane 5: Hep-G2 cell lysates with FUS monoclonal antibody, clone CL0190 (Cat # MAB15556).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with FUS monoclonal antibody, clone CL0190 (Cat # MAB15556) shows strong nuclear positivity in both renal glomeruli and tubuli.
Immunofluorescence
Immunofluorescent staining of HeLa cells with FUS monoclonal antibody, clone CL0190 (Cat # MAB15556) (Green) shows clear nuclear (without nucleoli). Microtubule and nuclear probes are visualized in red and blue respectively (where available).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human FUS.
Immunogen
Recombinant protein corresponding to human FUS.
Epitope
This antibody binds to an epitope located within the peptide sequence YGGQQQSYGQ as determined by overlapping synthetic peptides.
Sequence
SSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDR
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG1
Recommend Usage
Immunofluorescence (1-4 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:2500-1:5000)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of Lane 1: HeLa, Lane 2: A-431, Lane 3: MCF-7, Lane 4: U2-OS and Lane 5: Hep-G2 cell lysates with FUS monoclonal antibody, clone CL0190 (Cat # MAB15556).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with FUS monoclonal antibody, clone CL0190 (Cat # MAB15556) shows strong nuclear positivity in both renal glomeruli and tubuli.Immunofluorescence
Immunofluorescent staining of HeLa cells with FUS monoclonal antibody, clone CL0190 (Cat # MAB15556) (Green) shows clear nuclear (without nucleoli). Microtubule and nuclear probes are visualized in red and blue respectively (where available). -
Gene Info — FUS
Entrez GeneID
2521Protein Accession#
P35637Gene Name
FUS
Gene Alias
CHOP, FUS-CHOP, FUS1, TLS, TLS/CHOP, hnRNP-P2
Gene Description
fusion (involved in t(12;16) in malignant liposarcoma)
Omim ID
137070Gene Ontology
HyperlinkGene Summary
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq
Other Designations
FUS-CHOP fusion protein|FUS-CHOP protein fusion|Fusion gene in myxoid liposarcoma|fus-like protein|fus/tls-chop oncogene|heterogeneous nuclear ribonucleoprotein P2|translocated in liposarcoma
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Interactome
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Disease
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