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FUS monoclonal antibody, clone CL0190

  • Catalog # : MAB15556
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant human FUS.
  • Immunogen:
  • Recombinant protein corresponding to human FUS.
  • Sequence:
  • SSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDR
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein A purification
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Immunofluorescence (1-4 ug/mL)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:2500-1:5000)
    Western Blot (1:500-1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western Blot analysis of Lane 1: HeLa, Lane 2: A-431, Lane 3: MCF-7, Lane 4: U2-OS and Lane 5: Hep-G2 cell lysates with FUS monoclonal antibody, clone CL0190 (Cat # MAB15556).
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with FUS monoclonal antibody, clone CL0190 (Cat # MAB15556) shows strong nuclear positivity in both renal glomeruli and tubuli.
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescent staining of HeLa cells with FUS monoclonal antibody, clone CL0190 (Cat # MAB15556) (Green) shows clear nuclear (without nucleoli). Microtubule and nuclear probes are visualized in red and blue respectively (where available).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 2521
  • Gene Name:
  • FUS
  • Gene Alias:
  • CHOP,FUS-CHOP,FUS1,TLS,TLS/CHOP,hnRNP-P2
  • Gene Description:
  • fusion (involved in t(12;16) in malignant liposarcoma)
  • Gene Summary:
  • This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq
  • Other Designations:
  • FUS-CHOP fusion protein,FUS-CHOP protein fusion,Fusion gene in myxoid liposarcoma,fus-like protein,fus/tls-chop oncogene,heterogeneous nuclear ribonucleoprotein P2,translocated in liposarcoma
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