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Last updated: 2017/10/15

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S100B monoclonal antibody, clone S100B/1012 (AF488)

  • Catalog # : MAB15239
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against full length recombinant human S100B.
  • Immunogen:
  • Recombinant protein corresponding to full length human S100B.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 10-12
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Conjugation:
  • AF488
  • Purification:
  • Protein A/G purification
  • Isotype:
  • IgG2a, kappa
  • Recommend Usage:
  • Flow Cytometry (5 uL/106 cells or 5 uL/100 uL whole blood)
    Immunofluorescence (1:50-1:100)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
  • Storage Instruction:
  • Store at 4°C.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Immunofluorescence
  • Immunofluorescence
  • Confocal Immunofluorescent staining of A2058 cells with S100B monoclonal antibody, clone S100B/1012 (AF488) (Cat # MAB15239) (Green). F-actin filaments were labeled with DyLight 554 Phalloidin (Red). DAPI was used to stain the cell nuclei (Blue) (A); Confocal Immunofluorescent staining of A2058 cells with AF488 conjugated format of Isotype Control Monoclonal Antibody (IgG2a) (Green). F-actin filaments were labeled with DyLight 554 Phalloidin (Red). DAPI was used to stain the cell nuclei (Blue) (B, negative).
  • Flow Cytometry
  • Application Image
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 6285
  • Gene Name:
  • S100B
  • Gene Alias:
  • NEF,S100,S100beta
  • Gene Description:
  • S100 calcium binding protein B
  • Gene Summary:
  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000174958,S-100 calcium-binding protein, beta chain,S100 beta,S100 calcium binding protein, beta (neural),S100 calcium-binding protein, beta,S100 calcium-binding protein, beta (neural)
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