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Pan Cytokeratin monoclonal antibody, clone SPM115 + SPM116 

  • Catalog # : MAB15227
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native human Pan Cytokeratin.
  • Immunogen:
  • Human epidermal keratin.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 40-67
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein A/G purification
  • Isotype:
  • IgG
  • Recommend Usage:
  • Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL)
    Immunofluorescence (1-2 ug/mL)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL)
    Western Blotting (0.5-1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 10 mM PBS.
  • Storage Instruction:
  • Store at -20 to -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Publication Reference
  • Applications
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast carcinoma with Pan Cytokeratin monoclonal antibody, clone SPM115 + SPM116 (Cat # MAB15227).
  • Immunofluorescence
  • Flow Cytometry
  • Application Image
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunofluorescence
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 3848
  • Protein Accession#:
  • P04264;P12035;P19013;P13647;P02538;P04259;P48668;P05787;P13645;P02533;P19012;P08779;P08727
  • Gene Name:
  • KRT1
  • Gene Alias:
  • CK1,EHK1,K1,KRT1A
  • Gene Description:
  • keratin 1
  • Gene Summary:
  • The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq
  • Other Designations:
  • cytokeratin 1,epidermolytic hyperkeratosis 1,hair alpha protein,keratin, type II cytoskeletal 1
  • Gene Information
  • Entrez GeneID:
  • 3850
  • Protein Accession#:
  • P04264;P12035;P19013;P13647;P02538;P04259;P48668;P05787;P13645;P02533;P19012;P08779;P08727
  • Gene Name:
  • KRT3
  • Gene Alias:
  • CK3,FLJ95909,K3
  • Gene Description:
  • keratin 3
  • Gene Summary:
  • The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq
  • Other Designations:
  • 65 kDa cytokeratin,cytokeratin 3,keratin, type II cytoskeletal 3
  • Gene Information
  • Entrez GeneID:
  • 3851
  • Protein Accession#:
  • P04264;P12035;P19013;P13647;P02538;P04259;P48668;P05787;P13645;P02533;P19012;P08779;P08727
  • Gene Name:
  • KRT4
  • Gene Alias:
  • CK4,CYK4,FLJ31692,K4
  • Gene Description:
  • keratin 4
  • Gene Summary:
  • The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq
  • Other Designations:
  • cytokeratin 4,keratin, type II cytoskeletal 4
  • Gene Information
  • Entrez GeneID:
  • 3852
  • Protein Accession#:
  • P04264;P12035;P19013;P13647;P02538;P04259;P48668;P05787;P13645;P02533;P19012;P08779;P08727
  • Gene Name:
  • KRT5
  • Gene Alias:
  • CK5,DDD,EBS2,K5,KRT5A
  • Gene Description:
  • keratin 5
  • Gene Summary:
  • The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq
  • Other Designations:
  • 58 kda cytokeratin,epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types,keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types),keratin, type II cytoskeletal 5
  • Gene Information
  • Entrez GeneID:
  • 3853
  • Protein Accession#:
  • P04264;P12035;P19013;P13647;P02538;P04259;P48668;P05787;P13645;P02533;P19012;P08779;P08727
  • Gene Name:
  • KRT6A
  • Gene Alias:
  • CK6A,CK6C,CK6D,K6A,K6C,K6D,KRT6C,KRT6D
  • Gene Description:
  • keratin 6A
  • Gene Summary:
  • The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq
  • Other Designations:
  • 56 cytoskeletal type II keratin,K6D keratin,cytokeratin 6A,cytokeratin 6C,cytokeratin 6D,keratin 6C,keratin, epidermal type II, K6A,keratin, epidermal type II, K6C,keratin, type II cytoskeletal 6D,type II keratin isoform K6c
  • Gene Information
  • Entrez GeneID:
  • 3854
  • Protein Accession#:
  • P04264;P12035;P19013;P13647;P02538;P04259;P48668;P05787;P13645;P02533;P19012;P08779;P08727
  • Gene Name:
  • KRT6B
  • Gene Alias:
  • CK6B,K6B,KRTL1,PC2
  • Gene Description:
  • keratin 6B
  • Gene Summary:
  • The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq
  • Other Designations:
  • cytokeratin 6B,keratin, epidermal, type II, K6B,keratin, type II cytoskeletal 6B,keratin-like 1 (a type II keratin sequence)
  • Gene Information
  • Protein Accession#:
  • P04264;P12035;P19013;P13647;P02538;P04259;P48668;P05787;P13645;P02533;P19012;P08779;P08727
  • Gene Name:
  • KRT6C
  • Gene Alias:
  • K6E,KRT6E,MGC102925,MGC163455,MGC163457
  • Gene Description:
  • keratin 6C
  • Gene Summary:
  • Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq
  • Other Designations:
  • keratin 6E
  • Gene Information
  • Entrez GeneID:
  • 3856
  • Protein Accession#:
  • P04264;P12035;P19013;P13647;P02538;P04259;P48668;P05787;P13645;P02533;P19012;P08779;P08727
  • Gene Name:
  • KRT8
  • Gene Alias:
  • CARD2,CK8,CYK8,K2C8,K8,KO
  • Gene Description:
  • keratin 8
  • Gene Summary:
  • This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. [provided by RefSeq
  • Other Designations:
  • cytokeratin 8,keratin, type II cytoskeletal 8
  • Gene Information
  • Entrez GeneID:
  • 3858
  • Protein Accession#:
  • P04264;P12035;P19013;P13647;P02538;P04259;P48668;P05787;P13645;P02533;P19012;P08779;P08727
  • Gene Name:
  • KRT10
  • Gene Alias:
  • CK10,K10,KPP
  • Gene Description:
  • keratin 10
  • Gene Summary:
  • This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq
  • Other Designations:
  • cytokeratin 10
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