FOXP3 monoclonal antibody, clone SPM579
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Specifications
Product Description
Mouse monoclonal antibody raised against full length recombinant human FOXP3.
Immunogen
Recombinant protein corresponding to full length human FOXP3.
Host
Mouse
Theoretical MW (kDa)
47-55
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human testicle tumor with FOXP3 monoclonal antibody, clone SPM579 (Cat # MAB15225).Immunofluorescence
Flow Cytometry
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Gene Info — FOXP3
Entrez GeneID
50943Protein Accession#
Q9BZS1Gene Name
FOXP3
Gene Alias
AIID, DIETER, IPEX, JM2, MGC141961, MGC141963, PIDX, XPID
Gene Description
forkhead box P3
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000025832|immune dysregulation, polyendocrinopathy, enteropathy, X-linked|immunodeficiency, polyendocrinopathy, enteropathy, X-linked|scurfin
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Interactomes
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Diseases
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Publication Reference
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Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation.
Schubert LA, Jeffery E, Zhang Y, Ramsdell F, Ziegler SF.
The Journal of Biological Chemistry 2001 Oct; 276(40):37672.
Application:GSA, IF, WB-Tr, Human, HEK 293T cells, Jurkat cells, Recombinant proteins.
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Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation.
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