L1CAM monoclonal antibody, clone SPM275
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Specification
Product Description
Mouse monoclonal antibody raised against native human L1CAM.
Immunogen
Homogenous suspension of 16 week human fetal brain.
Host
Mouse
Theoretical MW (kDa)
220-240
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL)
Immunofluorescence (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunofluorescence
Flow Cytometry
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Gene Info — L1CAM
Entrez GeneID
3897Protein Accession#
P32004Gene Name
L1CAM
Gene Alias
CAML1, CD171, HSAS, HSAS1, MASA, MIC5, N-CAML1, S10, SPG1
Gene Description
L1 cell adhesion molecule
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant. [provided by RefSeq
Other Designations
OTTHUMP00000025992|antigen identified by monoclonal antibody R1|neural cell adhesion molecule L1
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Interactome
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Pathway
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Disease
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Publication Reference
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Monoclonal antibody UJ127.11 recognizes the human homologue of mouse L1 cell adhesion molecule.
Patel K, Kiely F, Rathjen F, Kemshead J.
Biochemical Society Transactions 1990 Apr; 18(2):274.
Application:IF, IP, IHC-Fr, IHC-P, WB-Ce, WB-Tr, Human, Mouse, Human brains, L1 cells.
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Monoclonal antibody UJ 127:11 detects a 220,000-240,000 kdal. glycoprotein present on a sub-set of neuroectodermally derived cells.
Kemshead JT, Fritschy J, Garson JA, Allan P, Coakham H, Brown S, Asser U.
International Journal of Cancer 1983 Feb; 31(2):187.
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Monoclonal antibody UJ127.11 recognizes the human homologue of mouse L1 cell adhesion molecule.
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