CSF2 monoclonal antibody, clone SPM469
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Specification
Product Description
Rat monoclonal antibody raised against full length recombinant human CSF2.
Immunogen
Recombinant protein corresponding to full length human CSF2.
Host
Rat
Theoretical MW (kDa)
22
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2a, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Frozen sections) (0.5-1 ug/mL)
Immunoprecipitation (0.5-1 ug/500 ug protein lysate)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Frozen sections)
Immunofluorescence
Immunoprecipitation
Flow Cytometry
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Gene Info — CSF2
Entrez GeneID
1437Protein Accession#
P04141Gene Name
CSF2
Gene Alias
GMCSF, MGC131935, MGC138897
Gene Description
colony stimulating factor 2 (granulocyte-macrophage)
Omim ID
138960Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq
Other Designations
colony stimulating factor 2|granulocyte-macrophage colony stimulating factor|molgramostin|sargramostim
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Interactome
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Pathway
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Disease
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Publication Reference
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Concomitant in vivo production of 19 different cytokines in human tonsils.
Andersson J, Abrams J, Björk L, Funa K, Litton M, Agren K, Andersson U.
Immunology 1994 Sep; 83(1):16.
Application:IHC-Fr, Human, Human tonsils.
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Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples.
Abrams JS, Roncarolo MG, Yssel H, Andersson U, Gleich GJ, Silver JE.
Immunological Reviews 1992 Jun; 127:5.
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Granulocyte/macrophage colony-stimulating factor and interleukin 3 release from human peripheral blood eosinophils and neutrophils.
Kita H, Ohnishi T, Okubo Y, Weiler D, Abrams JS, Gleich GJ.
The Journal of Experimental Medicine 1991 Sep; 174(3):745.
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Host-reactive CD4+ and CD8+ T cell clones isolated from a human chimera produce IL-5, IL-2, IFN-gamma and granulocyte/macrophage-colony-stimulating factor but not IL-4.
Bacchetta R, de Waal Malefijt R, Yssel H, Abrams J, de Vries JE, Spits H, Roncarolo MG.
The Journal of Immunology 1990 Feb; 144(3):902.
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Concomitant in vivo production of 19 different cytokines in human tonsils.
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