ESR2 monoclonal antibody, clone ESR2/686
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast carcinoma.
Flow Cytometry
Flow cytometric analysis of BT-474 cell line. Black: Cells alone. Grey: Isotype control. Green: AF488 lebeled ESR2 monoclonal antibody, clone ESR2/686.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human ESR2.
Immunogen
Recombinant protein corresponding to C-terminus of human ESR2.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2a
Recommend Usage
Flow Cytometry (0.5-1 ug/million cells)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast carcinoma.Immunofluorescence
Flow Cytometry
Flow cytometric analysis of BT-474 cell line. Black: Cells alone. Grey: Isotype control. Green: AF488 lebeled ESR2 monoclonal antibody, clone ESR2/686. -
Gene Info — ESR2
Entrez GeneID
2100Protein Accession#
Q92731Gene Name
ESR2
Gene Alias
ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2
Gene Description
estrogen receptor 2 (ER beta)
Omim ID
601663Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq
Other Designations
estrogen receptor beta|estrogen receptor beta 4
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Interactome
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Disease
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Publication Reference
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Evaluation of seven oestrogen receptor beta antibodies for immunohistochemistry, western blotting, and flow cytometry in human breast tissue.
Skliris GP, Parkes AT, Limer JL, Burdall SE, Carder PJ, Speirs V.
The Journal of Pathology 2002 Jun; 197(2):155.
Application：Flow Cyt, IHC-Fr, IHC-P, WB-Ce, Human, HCT-116 cells, Human breast tissues, HUVECs, MCF-7 cells, T-47D cells .
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Evaluation of seven oestrogen receptor beta antibodies for immunohistochemistry, western blotting, and flow cytometry in human breast tissue.
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