IGF1 monoclonal antibody, clone SPM406
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Specifications
Product Description
Mouse monoclonal antibody raised against native human IGF1.
Immunogen
Native purified human IGF1 protein.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/million cells)
Immunofluorescence (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at 4°C. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunofluorescence
Flow Cytometry
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Gene Info — IGF1
Entrez GeneID
3479Protein Accession#
P05019Gene Name
IGF1
Gene Alias
IGFI
Gene Description
insulin-like growth factor 1 (somatomedin C)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene
Other Designations
insulin-like growth factor 1|somatomedin C
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Insulin-like growth factor-1 (IGF-1): a neuroprotective trophic factor acting via the Akt kinase pathway.
Zheng WH, Kar S, Doré S, Quirion R.
Journal of Neural Transmission. Supplementum 2000 Jan; 60:261.
Application:IHC, Human, Human brains.
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Characterization of insulin-like growth factor 1 in human primary brain tumors.
Sandberg-Nordqvist AC, Ståhlbom PA, Reinecke M, Collins VP, von Holst H, Sara V.
Cancer Research 1993 Jun; 53(11):2475.
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Organization and sequence of the human insulin-like growth factor I gene. Alternative RNA processing produces two insulin-like growth factor I precursor peptides.
Rotwein P, Pollock KM, Didier DK, Krivi GG.
The Journal of Biological Chemistry 1986 Apr; 261(11):4828.
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Insulin-like growth factor-1 (IGF-1): a neuroprotective trophic factor acting via the Akt kinase pathway.
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