NF68 monoclonal antibody, clone NR4
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against native neurofilament 68.
Immunogen
Native purified pig Neurofilament 68.
Host
Mouse
Theoretical MW (kDa)
68
Reactivity
Human, Pig
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG1
Recommend Usage
Western Blot (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2-4 ug/mL)
Immunohistochemistry (Frozen sections) (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 1.2% sodium acetate (2 mg BSA, 0.01 mg sodium azide)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 1 mL of 1.2% sodium acetate or neutral PBS and concentration will be 100 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Frozen sections)
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Publication Reference
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Myotubularin-related 2 protein phosphatase and neurofilament light chain protein, both mutated in CMT neuropathies, interact in peripheral nerve.
Previtali SC, Zerega B, Sherman DL, Brophy PJ, Dina G, King RH, Salih MM, Feltri L, Quattrini A, Ravazzolo R, Wrabetz L, Monaco AP, Bolino A.
Human Molecular Genetics 2003 Jul; 12(14):1713.
Application：IF, IHC-P, WB-Tr, Human, Monkey, Sural nerve biopsies, COS-7 cells.
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Mutations in the neurofilament light chain gene (NEFL) cause early onset severe Charcot-Marie-Tooth disease.
Jordanova A, De Jonghe P, Boerkoel CF, Takashima H, De Vriendt E, Ceuterick C, Martin JJ, Butler IJ, Mancias P, Papasozomenos SCh, Terespolsky D, Potocki L, Brown CW, Shy M, Rita DA, Tournev I, Kremensky I, Lupski JR, Timmerman V.
Brain 2003 Mar; 126(Pt 3):590.
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Delayed maturation of regenerating myelinated axons in mice lacking neurofilaments.
Zhu Q, Couillard-Despres S, Julien JP.
Experimental Neurology 1997 Nov; 148(1):299.
Application：IF, WB-Ti, Mouse, Mouse nervous tissue samples.
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Myotubularin-related 2 protein phosphatase and neurofilament light chain protein, both mutated in CMT neuropathies, interact in peripheral nerve.
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