AURKB monoclonal antibody, clone AURKB/1521
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More Files
- More Functions
Western Blot
Western Blot analysis of Lane 1: recombinant protein and Lane 2: human liver lysate with AURKB monoclonal antibody, clone AURKB/1521 (Cat # MAB15055).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human AURKB.
Immunogen
Recombinant protein corresponding to amino acids 89-251 of human AURKB.
Host
Mouse
Theoretical MW (kDa)
39
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2b
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Western Blot analysis of Lane 1: recombinant protein and Lane 2: human liver lysate with AURKB monoclonal antibody, clone AURKB/1521 (Cat # MAB15055).Immunofluorescence
Flow Cytometry
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Gene Info — AURKB
Entrez GeneID
9212Protein Accession#
Q96GD4Gene Name
AURKB
Gene Alias
AIK2, AIM-1, AIM1, ARK2, AurB, IPL1, STK12, STK5
Gene Description
aurora kinase B
Omim ID
604970Gene Ontology
HyperlinkGene Summary
Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al., 2004 [PubMed 14767480]).[supplied by OMIM
Other Designations
aurora-1|aurora-B|serine/threonine kinase 12
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Interactome
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Disease
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Publication Reference
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Giant cell glioblastoma is associated with altered aurora b expression and concomitant p53 mutation.
Temme A, Geiger KD, Wiedemuth R, Conseur K, Pietsch T, Felsberg J, Reifenberger G, Tatsuka M, Hagel C, Westphal M, Berger H, Simon M, Weller M, Schackert G.
Journal of Neuropathology and Experimental Neurology 2010 Jun; 69(6):632.
Application：IHC-P, WB-Tr, Human, Human gliomas, U87-MG cells.
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Giant cell glioblastoma is associated with altered aurora b expression and concomitant p53 mutation.
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