CD1A monoclonal antibody, clone CBT6
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Specification
Product Description
Mouse monoclonal antibody raised against native human CD1A.
Immunogen
Native purified human CD1A.
Host
Mouse
Theoretical MW (kDa)
49
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2b, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunofluorescence
Flow Cytometry
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Gene Info — CD1A
Entrez GeneID
909Protein Accession#
P06126Gene Name
CD1A
Gene Alias
CD1, FCB6, HTA1, R4, T6
Gene Description
CD1a molecule
Omim ID
188370Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq
Other Designations
CD1A antigen|CD1A antigen, a polypeptide|OTTHUMP00000018907|T-cell surface antigen T6/Leu-6|T-cell surface glycoprotein CD1a|cluster of differentiation 1 A|cortical thymocyte antigen CD1A|differentiation antigen CD1-alpha-3|epidermal dendritic cell marker
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Interactome
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Pathway
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Disease
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Publication Reference
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The distribution of CD1 molecules in inflammatory neuropathy.
A Khalili-Shirazi, N A Gregson, M Londei, L Summers, R A Hughes.
Journal of the Neurological Sciences 1998 Jun; 158(2):154.
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The role of CD1 molecules in immune responses to infection.
J K Maher, M Kronenberg.
Current Opinion in Immunology 1997 Aug; 9(4):456.
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Structure and function of the CD1 family of MHC-like cell surface proteins.
Blumberg RS, Gerdes D, Chott A, Porcelli SA, Balk SP.
Immunological Reviews 1995 Oct; 147:5.
Application:Flow Cyt, IHC, Human, Mouse, Rabbit, B cells, Dendritic cells, Gastrointestinal tracts, Monocytes, T cells, Thymocytes.
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Analysis of CD1 molecules on haematological malignancies of myeloid and lymphoid origin. II. Intracellular detection of CD1 antigens.
Salamone MC, Roisman FR, Morelli AE, Noli MI, Fainboim L.
Disease Markers 1990 Sep; 8(5):275.
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The thymic differentiation markers T6 and M241 are two unusual MHC class I antigens.
M van de Rijn, P G Lerch, R W Knowles, C Terhorst.
The Journal of Immunology 1983 Aug; 131(2):851.
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Biochemical comparison of the T6 antigen and HLA-A,B antigens.
Lerch PG, van de Rijn M, Schrier P, Terhorst C.
Human Immunology 1983 Jan; 6(1):13.
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The distribution of CD1 molecules in inflammatory neuropathy.
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