TP63 monoclonal antibody, clone TP63/1786
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More Files
- More Functions
Western Blot
Western Blot analysis of Lane 1: recombinant protein, Lane 2: PC3 and Lane 3: HeLa cell lysates with TP63 monoclonal antibody, clone TP63/1786 (Cat # MAB15051).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human TP63.
Immunogen
Recombinant protein corresponding to amino acids 3-106 of human TP63.
Host
Mouse
Theoretical MW (kDa)
63
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2b, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Western Blot analysis of Lane 1: recombinant protein, Lane 2: PC3 and Lane 3: HeLa cell lysates with TP63 monoclonal antibody, clone TP63/1786 (Cat # MAB15051).Immunofluorescence
Flow Cytometry
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Gene Info — TP63
Entrez GeneID
8626Protein Accession#
Q9H3D4Gene Name
TP63
Gene Alias
AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L
Gene Description
tumor protein p63
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq
Other Designations
amplified in squamous cell carcinoma|chronic ulcerative stomatitis protein|keratinocyte transcription factor|transformation-related protein 63|tumor protein p53-competing protein|tumor protein p53-like|tumor protein p73-like
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Interactome
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Disease
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Publication Reference
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p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.
Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dötsch V, Andrews NC, Caput D, McKeon F.
Molecular Cell 1998 Sep; 2(3):305.
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p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.
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