CANX monoclonal antibody, clone CANX/1541
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human renal cell carcinoma (A, B) and human small intestinal carcinoma (C) with CANX monoclonal antibody, clone CANX/1541 (Cat # MAB15046).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human CANX.
Immunogen
Recombinant protein corresponding to N-terminus of human CANX.
Host
Mouse
Theoretical MW (kDa)
90
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2b, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human renal cell carcinoma (A, B) and human small intestinal carcinoma (C) with CANX monoclonal antibody, clone CANX/1541 (Cat # MAB15046).Immunofluorescence
Flow Cytometry
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Gene Info — CANX
Entrez GeneID
821Protein Accession#
P27824Gene Name
CANX
Gene Alias
CNX, FLJ26570, IP90, P90
Gene Description
calnexin
Omim ID
114217Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq
Other Designations
major histocompatibility complex class I antigen-binding protein p88
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Interactome
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Pathway
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Publication Reference
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The Merck Frosst Award Lecture 1994/La conference Merck Frosst 1994. Calnexin: a molecular chaperone with a taste for carbohydrate.
D B Williams.
Biochemistry and Cell Biology 1995 Mar; 73(3-4):123.
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The Merck Frosst Award Lecture 1994/La conference Merck Frosst 1994. Calnexin: a molecular chaperone with a taste for carbohydrate.
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