TSHR, A Chain monoclonal antibody, clone SPM223
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Specifications
Product Description
Mouse monoclonal antibody raised against full length recombinant human TSHR, A Chain.
Immunogen
Recombinant protein corresponding to full length human TSHR, A Chain.
Host
Mouse
Theoretical MW (kDa)
62
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human thyroid carcinoma with TSHR, A Chain monoclonal antibody, clone SPM223 (Cat # MAB15018).Immunofluorescence
Flow Cytometry
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Gene Info — TSHR
Entrez GeneID
7253Protein Accession#
P16473Gene Name
TSHR
Gene Alias
CHNG1, LGR3, MGC75129, hTSHR-I
Gene Description
thyroid stimulating hormone receptor
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
seven transmembrane helix receptor|thyroid stimulating hormone receptor, isoform 2|thyrotropin receptor|thyrotropin receptor-I, hTSHR-I
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Subunit structure of thyrotropin receptors expressed on the cell surface.
K Tanaka, G D Chazenbalk, S M McLachlan, B Rapoport.
The Journal of Biological Chemistry 1999 Nov; 274(48):33979.
Application:IP, Hamster, CHO cells.
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Subunit structure of thyrotropin receptors expressed on the cell surface.
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