TIMP2 monoclonal antibody, clone SPM356
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of human TIMP2.
Immunogen
A synthetic peptide corresponding to amino acids 56-66 at N-terminus of human TIMP2.
Sequence
DSGNDIYGNPI
Host
Mouse
Theoretical MW (kDa)
21
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2a, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human placenta with TIMP2 monoclonal antibody, clone SPM356 (Cat # MAB15011).Immunofluorescence
Flow Cytometry
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Gene Info — TIMP2
Entrez GeneID
7077Protein Accession#
P16035Gene Name
TIMP2
Gene Alias
CSC-21K
Gene Description
TIMP metallopeptidase inhibitor 2
Omim ID
188825Gene Ontology
HyperlinkGene Summary
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq
Other Designations
tissue inhibitor of metalloproteinase 2|tissue inhibitor of metalloproteinases 2
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Interactome
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Disease
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Publication Reference
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The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers.
Natalie Jeffery, Mairi H McLean, Emad M El-Omar, Graeme I Murray.
Histopathology 2009 Jun; 54(7):820.
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Matrix metalloproteinases and their inhibitors in gastric cancer.
Murray GI, Duncan ME, Arbuckle E, Melvin WT, Fothergill JE.
Gut 1998 Dec; 43(6):791.
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The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers.
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