THBD monoclonal antibody, clone THBD/1591
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More Files
- More Functions
Western Blot
Western Blot analysis of Lane 1: recombinant protein and Lane 2: THP1 cell lysate with THBD monoclonal antibody, clone THBD/1591 (Cat # MAB15007).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cervical carcinoma (A), human bladder carcinoma (B) and human placenta (C) with THBD monoclonal antibody, clone THBD/1591 (Cat # MAB15007).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human THBD.
Immunogen
Recombinant protein corresponding to amino acids 69-194 of human THBD.
Host
Mouse
Theoretical MW (kDa)
~100
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2b, kappa
Recommend Usage
ELISA (2-4 ug/mL for coating)
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Western Blot analysis of Lane 1: recombinant protein and Lane 2: THP1 cell lysate with THBD monoclonal antibody, clone THBD/1591 (Cat # MAB15007).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cervical carcinoma (A), human bladder carcinoma (B) and human placenta (C) with THBD monoclonal antibody, clone THBD/1591 (Cat # MAB15007).Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
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Gene Info — THBD
Entrez GeneID
7056Protein Accession#
P07204Gene Name
THBD
Gene Alias
CD141, THRM, TM
Gene Description
thrombomodulin
Omim ID
188040Gene Ontology
HyperlinkGene Summary
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq
Other Designations
CD141 antigen|OTTHUMP00000030415|fetomodulin
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Interactome
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Pathway
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Disease
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Publication Reference
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Thrombomodulin as a marker of vascular and lymphatic tumours.
Appleton MA, Attanoos RL, Jasani B.
Histopathology 1996 Aug; 29(2):153.
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Thrombomodulin as a marker of vascular and lymphatic tumours.
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