SOX2 monoclonal antibody, clone SOX2/1791
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cervix cancer with SOX2 monoclonal antibody, clone SOX2/1791 (Cat # MAB14987).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human SOX2.
Immunogen
Recombinant protein corresponding to amino acids 176-305 of human SOX2.
Host
Mouse
Theoretical MW (kDa)
34
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2b, kappa
Recommend Usage
ELISA (2-4 ug/mL for coating)
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cervix cancer with SOX2 monoclonal antibody, clone SOX2/1791 (Cat # MAB14987).Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
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Gene Info — SOX2
Entrez GeneID
6657Protein Accession#
P48431Gene Name
SOX2
Gene Alias
ANOP3, MCOPS3, MGC2413
Gene Description
SRY (sex determining region Y)-box 2
Gene Ontology
HyperlinkGene Summary
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq
Other Designations
SRY-related HMG-box gene 2|sex-determining region Y-box 2|transcription factor SOX2
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Interactome
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Disease
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Publication Reference
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Ancestry and diversity of the HMG box superfamily.
Laudet V, Stehelin D, Clevers H.
Nucleic Acids Research 1993 May; 21(10):2493.
Application：WB-Ce, WB-Tr, Human, Mammalian cells.
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Ancestry and diversity of the HMG box superfamily.
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