SELPLG monoclonal antibody, clone PSGL1/1601
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant human SELPLG.
Immunogen
Recombinant protein corresponding to full length human SELPLG.
Host
Mouse
Theoretical MW (kDa)
43-120
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human spleen (A) and human tonsil (B) with SELPLG monoclonal antibody, clone PSGL1/1601 (Cat # MAB14985).Immunofluorescence
Flow Cytometry
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Gene Info — SELPLG
Entrez GeneID
6404Protein Accession#
Q14242Gene Name
SELPLG
Gene Alias
CD162, CLA, PSGL-1, PSGL1
Gene Description
selectin P ligand
Omim ID
600738Gene Ontology
HyperlinkGene Summary
SELPLG is the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. The organization of the SELPG gene closely resembles that of CD43 and the human platelet glycoprotein GpIb-alpha both of which have an intron in the 5-prime-noncoding region, a long second exon containing the complete coding region, and TATA-less promoters. [provided by RefSeq
Other Designations
cutaneous lymphocyte-associated associated antigen
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Interactome
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Pathway
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Disease
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Publication Reference
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Structure and function of the selectin ligand PSGL-1.
Cummings RD.
Brazilian Journal of Medical and Biological Research 1999 May; 32(5):519.
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The biology of P-selectin glycoprotein ligand-1: its role as a selectin counterreceptor in leukocyte-endothelial and leukocyte-platelet interaction.
Yang J, Furie BC, Furie B.
Thrombosis and Haemostasis 1999 Jan; 81(1):1.
Application:Func, IHC, WB-Tr, Human, Rat, Kidneys, Mammalian cells.
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Structure and function of the selectin ligand PSGL-1.
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