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S100B monoclonal antibody, clone 4C4.9 + S100B/1012

  • Catalog # : MAB14983
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against S100B.
  • Immunogen:
  • Native purified S100 from bovine brain and recombinant protein corresponding to full length of human S100B.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 10-12
  • Reactivity:
  • Bovine, Human
  • Form:
  • Liquid
  • Purification:
  • Protein A/G purification
  • Isotype:
  • IgG2a, kappa
  • Recommend Usage:
  • Flow Cytometry (0.5-1 ug/106 cells)
    Immunofluorescence (1-2 ug/mL)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL)
    Western Blotting (0.5-1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 10 mM PBS.
  • Storage Instruction:
  • Store at -20 to -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Publication Reference
  • Applications
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human melanoma with S100B monoclonal antibody, clone 4C4.9 + S100B/1012 (Cat # MAB14983).
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescent staining of A2058 cells with S100B monoclonal antibody, clone 4C4.9 + S100B/1012 (Cat # MAB14983) (Green). Blue: DAPI was used to stain the cell nuclei. Red: F-actin filaments were labeled with DyLight 554 Phalloidin.
  • Flow Cytometry
  • Application Image
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Flow Cytometry
  • Gene Information
  • Protein Accession#:
  • P02638;P04271
  • Gene Name:
  • S100B
  • Gene Alias:
  • MGC128275
  • Gene Description:
  • S100 calcium binding protein B
  • Other Designations:
  • S100 protein, beta polypeptide
  • Gene Information
  • Entrez GeneID:
  • 6285
  • Protein Accession#:
  • P02638;P04271
  • Gene Name:
  • S100B
  • Gene Alias:
  • NEF,S100,S100beta
  • Gene Description:
  • S100 calcium binding protein B
  • Gene Summary:
  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000174958,S-100 calcium-binding protein, beta chain,S100 beta,S100 calcium binding protein, beta (neural),S100 calcium-binding protein, beta,S100 calcium-binding protein, beta (neural)
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