S100A1 monoclonal antibody, clone S1/61
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human melanoma with S100A1 monoclonal antibody, clone S1/61 (Cat # MAB14975).
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Specification
Product Description
Mouse monoclonal antibody raised against native human S100A1.
Immunogen
Native purified human S100 (conjugated with methylated BSA).
Host
Mouse
Theoretical MW (kDa)
10-12
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human melanoma with S100A1 monoclonal antibody, clone S1/61 (Cat # MAB14975).Immunofluorescence
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Gene Info — S100A1
Entrez GeneID
6271Protein Accession#
P23297Gene Name
S100A1
Gene Alias
S100, S100-alpha, S100A
Gene Description
S100 calcium binding protein A1
Omim ID
176940Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq
Other Designations
OTTHUMP00000035100|S100 alpha|S100 calcium-binding protein A1|S100 protein, alpha polypeptide
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Interactome
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Disease
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Publication Reference
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New sites of human S-100 immunoreactivity detected with monoclonal antibodies.
Vanstapel MJ, Gatter KC, de Wolf-Peeters C, Mason DY, Desmet VD.
American Journal of Clinical Pathology 1986 Feb; 85(2):160.
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Production of monoclonal antibodies directed against antigenic determinants common to the alpha- and beta-chain of bovine brain S-100 protein.
Vanstapel MJ, Peeters B, Cordell J, Heyns W, De Wolf-Peeters C, Desmet V, Mason D.
Laboratory Investigation 1985 Feb; 52(2):232.
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New sites of human S-100 immunoreactivity detected with monoclonal antibodies.
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