BCL6 monoclonal antibody, clone BCL6/1527
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human BCL6.
Immunogen
Recombinant protein corresponding to amino acids 256-389 of human BCL6.
Host
Mouse
Theoretical MW (kDa)
95
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% sodium azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human tonsil with BCL6 monoclonal antibody, clone BCL6/1527 (Cat # MAB14972).Immunofluorescence
Flow Cytometry
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Gene Info — BCL6
Entrez GeneID
604Protein Accession#
P41182Gene Name
BCL6
Gene Alias
BCL5, BCL6A, LAZ3, ZBTB27, ZNF51
Gene Description
B-cell CLL/lymphoma 6
Omim ID
109565Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq
Other Designations
B-cell lymphoma 6 protein|B-cell lymphoma 6 protein transcript|cys-his2 zinc finger transcription factor|lymphoma-associated zinc finger gene on chromosome 3|zinc finger protein 51|zinc finger transcription factor BCL6S
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Interactome
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Disease
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Publication Reference
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Genetic immunization: a new monoclonal antibody for the detection of BCL-6 protein in paraffin sections.
Garcia JF, Garcia JF, Maestre L, Lucas E, Sanchez-Verde L, Romero-Chala S, Piris MA, Roncador G.
The Journal of Histochemistry and Cytochemistry 2006 Jan; 54(1):31.
Application:ELISA, ICC, IHC- Fr, IHC-P, WB-Ce, WB-Ti, Human, AKATA cells, DB cells, Human B-CLL lymphomas, Human diffuse large B-cell lymphoma, Human tonsil, KARPAS-422 cells, Mutu-1 cells, RAMOS cells, REH cells.
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Detection of germinal center B-cell lymphoma in archival specimens: critical evaluation of Bcl-6 protein expression in diffuse large B-cell lymphoma of the tonsil.
Ree HJ, Ohsima K, Aozasa K, Takeuchi K, Kim CW, Yang WI, Huh JY, Lee SS, Ko YH, Kwon MS, Cho EY, Choi YL, Rhee JC, Kikuchi M, Mori S.
Human Pathology 2003 Jun; 34(6):610.
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Molecular pathogenesis of non-Hodgkin's lymphoma: the role of Bcl-6.
Pasqualucci L, Bereshchenko O, Niu H, Klein U, Basso K, Guglielmino R, Cattoretti G, Dalla-Favera R.
Leukemia & Lymphoma 2003 Jan; 44 Suppl 3:S5.
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Genetic immunization: a new monoclonal antibody for the detection of BCL-6 protein in paraffin sections.
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