ACTA2 monoclonal antibody, clone 1A4
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of ACTA2.
Immunogen
A synthetic peptide corresponding to N-terminus of human ACTA2.
Host
Mouse
Theoretical MW (kDa)
42
Reactivity
Human, Mouse, Rat
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG2a
Recommend Usage
Western Blot (2 ug/mL)
Immunohistochemistry (Frozen sections) (0.3-1.2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 1.2% sodium acetate (2 mg BSA, 0.01 mg sodium azide)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 1 mL of 1.2% sodium acetate or neutral PBS and concentration will be 100 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Frozen sections)
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Gene Info — ACTA2
Entrez GeneID
59Gene Name
ACTA2
Gene Alias
AAT6, ACTSA
Gene Description
actin, alpha 2, smooth muscle, aorta
Omim ID
102620Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000020042|alpha 2 actin|alpha-cardiac actin|growth-inhibiting gene 46
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Interactome
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Pathway
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Disease
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Publication Reference
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Dehydromevalonolactone ameliorates liver fibrosis and inflammation by repressing activation of NLRP3 inflammasome.
Wei-Xiao Niu, Yun-Yang Bao, Na Zhang, Zhen-Ning Lu, Mao-Xu Ge, Yi-Ming Li, Yi Li, Ming-Hua Chen, Hong-Wei He.
Bioorganic Chemistry 2022 Jun; 127:105971.
Application:WB-Ce, Human, Rat, LX-2 cells, Rat liver.
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Smooth muscle alpha-actin gene requires two E-boxes for proper expression in vivo and is a target of class I basic helix-loop-helix proteins.
Kumar MS, Hendrix JA, Johnson AD, Owens GK.
Circulation Research 2003 May; 92(8):840.
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Dehydromevalonolactone ameliorates liver fibrosis and inflammation by repressing activation of NLRP3 inflammasome.
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