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ACACA/ACACB (phospho S79) monoclonal antibody, clone RM270

  • Catalog # : MAB14918
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against synthetic phosphopeptide of human ACACA/ACACB.
  • Immunogen:
  • Synthetic phosphopeptide corresponding to residues surrounding S79 of human ACACA/ACACB.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein A purification
  • Isotype:
  • IgG
  • Recommend Usage:
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:1000-1:2000)
    Western Blotting (1:1000-1:5000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (50% glycerol, 1% BSA, 0.09% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western Blot analysis of A431 cell lysate Lane 1: nontreated and Lane 2: treated with Lambda Protein Phosphatase with ACACA/ACACB (phospho S79) monoclonal antibody, clone RM270 (Cat # MAB14918).
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast cancer with ACACA/ACACB (phospho S79) monoclonal antibody, clone RM270 (Cat # MAB14918).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 31
  • Protein Accession#:
  • Q13085;O00763
  • Gene Name:
  • ACACA
  • Gene Alias:
  • ACAC,ACC,ACC1,ACCA
  • Gene Description:
  • acetyl-Coenzyme A carboxylase alpha
  • Gene Summary:
  • Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • ACC-alpha,OTTHUMP00000164069,acetyl-CoA carboxylase 1,acetyl-CoA carboxylase-alpha
  • Gene Information
  • Entrez GeneID:
  • 32
  • Protein Accession#:
  • Q13085;O00763
  • Gene Name:
  • ACACB
  • Gene Alias:
  • ACC2,ACCB,HACC275
  • Gene Description:
  • acetyl-Coenzyme A carboxylase beta
  • Gene Summary:
  • Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq
  • Other Designations:
  • acetyl-CoA carboxylase 2
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