CD27 monoclonal antibody, clone LPFS2/1611
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human tonsil with CD27 monoclonal antibody, clone LPFS2/1611 (Cat # MAB14899).
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant human CD27.
Immunogen
Recombinant protein corresponding to human CD27 (exact sequence is proprietary).
Host
Mouse
Reactivity
Human
Specificity
Recognizes a protein of a disulfide-linked 120kDa dimer which identified as CD27.
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1
Recommend Usage
Flow Cytometry (0.5-1 ug/million cells)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA and 0.05% azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human tonsil with CD27 monoclonal antibody, clone LPFS2/1611 (Cat # MAB14899).Immunofluorescence
Flow Cytometry
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Gene Info — CD27
Entrez GeneID
939Gene Name
CD27
Gene Alias
MGC20393, S152, T14, TNFRSF7, Tp55
Gene Description
CD27 molecule
Omim ID
186711Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq
Other Designations
CD27 antigen|CD27L receptor|T cell activation antigen CD27|T cell antivation antigen S152|tumor necrosis factor receptor superfamily, member 7
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Interactome
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Pathway
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Disease
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Publication Reference
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Expression of the T-cell activation antigens CD27 and CD28 in normal and psoriatic skin.
De Rie MA, Cairo I, Van Lier RA, Bos JD.
Clinical and Experimental Dermatology 1996 Mar; 21(2):104.
Application：IHC-Fr, Human, Human skin biopsies.
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Expression of the T-cell activation antigens CD27 and CD28 in normal and psoriatic skin.
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