TIA1 monoclonal antibody, clone TIA1/1313
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot (Cell lysate) analysis with TIA1 monoclonal antibody, clone TIA1/1313 (Cat # MAB14897):
1. HepG2 cell line
2. PC3 cell line
3. HeLa cell line
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human TIA1.
Immunogen
Recombinant protein corresponding to amino acids 279-380 of human TIA1 (exact sequence is proprietary).
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG2b
Recommend Usage
Flow Cytometry (0.5-1 ug/million cells)
Immunofluorescence (1-2 ug/mL)
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA and 0.05% azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot (Cell lysate) analysis with TIA1 monoclonal antibody, clone TIA1/1313 (Cat # MAB14897):
1. HepG2 cell line
2. PC3 cell line
3. HeLa cell lineImmunofluorescence
Flow Cytometry
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Gene Info — TIA1
Entrez GeneID
7072Gene Name
TIA1
Gene Alias
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Gene Description
TIA1 cytotoxic granule-associated RNA binding protein
Omim ID
603518Gene Ontology
HyperlinkGene Summary
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq
Other Designations
T-cell-restricted intracellular antigen-1|TIA1 cytotoxic granule-associated RNA-binding protein|TIA1 protein|cytotoxic granule-associated RNA-binding protein|nucleolysin TIA-1 isoform p40|p40-TIA-1 (containing p15-TIA-1)
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Interactome
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Publication Reference
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TIA-1: structural and functional studies on a new class of cytolytic effector molecule.
Anderson P.
Current Topics in Microbiology and Immunology 1995 Jan; 198:131.
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TIA-1: structural and functional studies on a new class of cytolytic effector molecule.
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