ATRX monoclonal antibody, clone 39f
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human pancreas with ATRX monoclonal antibody, clone 39f (Cat # MAB14880).
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant human ATRX.
Immunogen
Recombinant protein corresponding to full length human ATRX.
Host
Mouse
Theoretical MW (kDa)
280
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human pancreas with ATRX monoclonal antibody, clone 39f (Cat # MAB14880).Immunofluorescence
Flow Cytometry
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Gene Info — ATRX
Entrez GeneID
546Protein Accession#
P46100Gene Name
ATRX
Gene Alias
ATR2, MGC2094, MRXHF1, RAD54, RAD54L, SFM1, SHS, XH2, XNP, ZNF-HX
Gene Description
alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
DNA dependent ATPase and helicase|OTTHUMP00000024265|OTTHUMP00000062079|X-linked nuclear protein|Zinc finger helicase|helicase 2, X-linked|transcriptional regulator ATRX
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Interactome
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Disease
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Publication Reference
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Human cytomegalovirus protein pp71 displaces the chromatin-associated factor ATRX from nuclear domain 10 at early stages of infection.
Lukashchuk V, McFarlane S, Everett RD, Preston CM.
Journal of Virology 2008 Dec; 82(24):12543.
Application：IF, WB-Ce, Human, HFFF2 cells.
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Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes.
McDowell TL, Gibbons RJ, Sutherland H, O'Rourke DM, Bickmore WA, Pombo A, Turley H, Gatter K, Picketts DJ, Buckle VJ, Chapman L, Rhodes D, Higgs DR.
PNAS 1999 Nov; 96(24):13983.
Application：ELISA, IF, WB-Ce, Human, Mouse, HeLa, L929 cells, Human B lymphocytes.
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Human cytomegalovirus protein pp71 displaces the chromatin-associated factor ATRX from nuclear domain 10 at early stages of infection.
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