NOX4 monoclonal antibody, clone NOX4/1245
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant human NOX4.
Immunogen
Recombinant protein corresponding to full length human NOX4.
Host
Mouse
Theoretical MW (kDa)
70
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2b, kappa
Recommend Usage
ELISA
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (0.5-1 ug/mL)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
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Gene Info — NOX4
Entrez GeneID
50507Protein Accession#
Q9NPH5Gene Name
NOX4
Gene Alias
KOX, KOX-1, RENOX
Gene Description
NADPH oxidase 4
Omim ID
605261Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants
Other Designations
kidney superoxide-producing NADPH oxidase|renal NAD(P)H-oxidase
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Interactome
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Disease
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Publication Reference
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A novel superoxide-producing NAD(P)H oxidase in kidney.
Shiose A, Kuroda J, Tsuruya K, Hirai M, Hirakata H, Naito S, Hattori M, Sakaki Y, Sumimoto H.
The Journal of Biological Chemistry 2001 Jan; 276(2):1417.
Application：IHC-P, WB-Ce, WB-Re, WB-Tr, Human, Monkey, Mouse, COS-7 cells, HEK 293 cells, Human renal cortex, KPK13 cells, Neutrophils, NIH/3T3 cells.
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Identification of renox, an NAD(P)H oxidase in kidney.
Geiszt M, Kopp JB, Várnai P, Leto TL.
PNAS 2000 Jul; 97(14):8010.
Application：IHC, WB-Ti, Human, Human kidney.
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A novel superoxide-producing NAD(P)H oxidase in kidney.
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