NKX2-2 monoclonal antibody, clone NX2/1524
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human Ewing's sarcoma (A, B) with NKX2-2 monoclonal antibody, clone NX2/1524 (Cat # MAB14856).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human NKX2-2.
Immunogen
Recombinant protein corresponding to amino acids 1-119 of human NKX2-2.
Host
Mouse
Theoretical MW (kDa)
40-50
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human Ewing's sarcoma (A, B) with NKX2-2 monoclonal antibody, clone NX2/1524 (Cat # MAB14856).Immunofluorescence
Flow Cytometry
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Gene Info — NKX2-2
Entrez GeneID
4821Protein Accession#
O95096Gene Name
NKX2-2
Gene Alias
NKX2.2, NKX2B
Gene Description
NK2 homeobox 2
Omim ID
604612Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq
Other Designations
NK-2 homolog B|NK2 transcription factor related, locus 2|NK2 transcription factor-like protein B|OTTHUMP00000030405|homeobox protein NK-2 homolog B
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Interactome
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Pathway
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Disease
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Publication Reference
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NKX2.2 Is a Useful Immunohistochemical Marker for Ewing Sarcoma.
Yoshida A, Sekine S, Tsuta K, Fukayama M, Furuta K, Tsuda H.
The American Journal of Surgical Pathology 2012 Jul; 36(7):993.
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Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors.
Wang YC, Gallego-Arteche E, Iezza G, Yuan X, Matli MR, Choo SP, Zuraek MB, Gogia R, Lynn FC, German MS, Bergsland EK, Donner DB, Warren RS, Nakakura EK.
Endocrine-Related Cancer 2009 Mar; 16(1):267.
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NKX2.2 Is a Useful Immunohistochemical Marker for Ewing Sarcoma.
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