ABCC1 monoclonal antibody, clone MRP1/1344
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant human ABCC1.
Immunogen
Recombinant protein corresponding to full length human ABCC1.
Host
Mouse
Theoretical MW (kDa)
190
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2a
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (0.5-1 ug/mL)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunofluorescence
Flow Cytometry
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Gene Info — ABCC1
Entrez GeneID
4363Protein Accession#
P33527Gene Name
ABCC1
Gene Alias
ABC29, ABCC, DKFZp686N04233, DKFZp781G125, GS-X, MRP, MRP1
Gene Description
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Omim ID
158343Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms. [provided by RefSeq
Other Designations
ATP-binding cassette, sub-family C, member 1|LTC4 transporter|OTTHUMP00000045904|leukotriene C(4) transporter|multidrug resistance protein|multiple drug resistance protein 1|multiple drug resistance-associated protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Multidrug resistance associated genes MRP1, MRP2 and MRP3 in primary and anthracycline exposed breast cancer.
Faneyte IF, Kristel PM, van de Vijver MJ.
Anticancer Research 2004 Sep; 24(5A):2931.
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Multidrug resistance associated genes MRP1, MRP2 and MRP3 in primary and anthracycline exposed breast cancer.
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