MCM7 monoclonal antibody, clone MCM7/1466
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot analysis of Lane 1: HeLa, Lane 2: Raji and Lane 3: HepG2 cell lysates with MCM7 monoclonal antibody, clone MCM7/1466 (Cat # MAB14845).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human tonsil with MCM7 monoclonal antibody, clone MCM7/1466 (Cat # MAB14845).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human MCM7.
Immunogen
Recombinant protein corresponding to amino acids 195-319 of human MCM7.
Host
Mouse
Theoretical MW (kDa)
88
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2b
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
Western Blot analysis of Lane 1: HeLa, Lane 2: Raji and Lane 3: HepG2 cell lysates with MCM7 monoclonal antibody, clone MCM7/1466 (Cat # MAB14845).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human tonsil with MCM7 monoclonal antibody, clone MCM7/1466 (Cat # MAB14845).Immunofluorescence
Flow Cytometry
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Gene Info — MCM7
Entrez GeneID
4176Protein Accession#
P33993Gene Name
MCM7
Gene Alias
CDABP0042, CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS-146
Gene Description
minichromosome maintenance complex component 7
Omim ID
600592Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
DNA replication licensing factor MCM7|MCM7 minichromosome maintenance deficient 7|homolog of S. cerevisiae Cdc47|minichromosome maintenance deficient 7
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Interactome
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Pathway
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Disease
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Publication Reference
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A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication.
Koonin EV.
Nucleic Acids Research 1993 Jun; 21(11):2541.
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A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication.
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