ITGB3 monoclonal antibody, clone Y2/51
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Specification
Product Description
Mouse monoclonal antibody raised against native human ITGB3.
Immunogen
Phytohemagglutinin (PHA)-stimulated peripheral blood cells.
Host
Mouse
Theoretical MW (kDa)
105, 90
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
Immunohistochemistry (Frozen sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human spleen with ITGB3 monoclonal antibody, clone Y2/51 (Cat # MAB14824).Immunohistochemistry (Frozen sections)
Immunofluorescence
Flow Cytometry
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Gene Info — ITGB3
Entrez GeneID
3690Protein Accession#
P05106Gene Name
ITGB3
Gene Alias
CD61, GP3A, GPIIIa
Gene Description
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Omim ID
173470Gene Ontology
HyperlinkGene Summary
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq
Other Designations
integrin beta chain, beta 3|platelet glycoprotein IIIa
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Interactome
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Pathway
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Disease
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Publication Reference
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The immunohistological detection of platelets, megakaryocytes and thrombi in routinely processed specimens.
Gatter KC, Cordell JL, Turley H, Heryet A, Kieffer N, Anstee DJ, Mason DY.
Histopathology 1988 Sep; 13(3):257.
Application:IHC, WB-Ce, Mouse, Platelets, Megakaryocytes.
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The immunohistological detection of platelets, megakaryocytes and thrombi in routinely processed specimens.
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