ALPL monoclonal antibody, clone ALPL/597
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant human ALPL.
Immunogen
Recombinant protein corresponding to full length human ALPL.
Host
Mouse
Theoretical MW (kDa)
55
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human endometrial carcinoma (A), human testicular carcinoma (B), human ovarian carcinoma (C) and human colon carcinoma (D) with ALPL monoclonal antibody, clone ALPL/597 (Cat # MAB14793).Immunofluorescence
Flow Cytometry
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Gene Info — ALPL
Entrez GeneID
249Protein Accession#
P05186Gene Name
ALPL
Gene Alias
AP-TNAP, FLJ40094, FLJ93059, HOPS, MGC161443, MGC167935, TNAP, TNSALP
Gene Description
alkaline phosphatase, liver/bone/kidney
Gene Ontology
HyperlinkGene Summary
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000002971|OTTHUMP00000002972|alkaline phosphatase, tissue-nonspecific isozyme|alkaline phosphomonoesterase|glycerophosphatase|liver/bone/kidney-type alkaline phosphatase|tissue non-specific alkaline phosphatase|tissue-nonspecific ALP
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Interactome
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Pathway
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Disease
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Publication Reference
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Human placental and intestinal alkaline phosphatase genes map to 2q34-q37.
Griffin CA, Smith M, Henthorn PS, Harris H, Weiss MJ, Raducha M, Emanuel BS.
American Journal of Human Genetics 1987 Dec; 41(6):1025.
Application:ELISA, IHC-Fr, IHC-P, WB-Ce, WB-Tr, Human, Cancer, Mammalian cells, Serum.
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Diagnostic aspects of alkaline phosphatase and its isoenzymes.
Moss DW.
Clinical Biochemistry 1987 Aug; 20(4):225.
Application:ELISA, Human, Human serum.
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Human placental and intestinal alkaline phosphatase genes map to 2q34-q37.
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