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F13A1 monoclonal antibody, clone F13A1/1447

  • Catalog # : MAB14777
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant human F13A1.
  • Immunogen:
  • Recombinant protein corresponding to amino acids 46-181 of human F13A1.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 83
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein A/G purification
  • Isotype:
  • IgG2a
  • Recommend Usage:
  • ELISA
    Flow Cytometry (0.5-1 ug/106 cells)
    Immunofluorescence (0.5-1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 10 mM PBS.
  • Storage Instruction:
  • Store at -20 to -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Publication Reference
  • Applications
  • Immunofluorescence
  • ELISA
  • Flow Cytometry
  • Application Image
  • Immunofluorescence
  • ELISA
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 2162
  • Gene Name:
  • F13A1
  • Gene Alias:
  • F13A
  • Gene Description:
  • coagulation factor XIII, A1 polypeptide
  • Gene Summary:
  • This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq
  • Other Designations:
  • FSF, A subunit,TGase,bA525O21.1 (coagulation factor XIII, A1 polypeptide),coagulation factor XIII A1 subunit,coagulation factor XIII, A polypeptide,factor XIIIa,fibrin stabilizing factor, A subunit,fibrinoligase,protein-glutamine gamma-glutamyltransferase
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