ALDH1A1 monoclonal antibody, clone ALDH1A1/1381
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More Files
- More Functions
Western Blot
Western Blot analysis of Lane 1: K562 and Lane 2: lung lysates with ALDH1A1 monoclonal antibody, clone ALDH1A1/1381 (Cat # MAB14776).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon carcinoma (A) and human testicular carcinoma (B) with ALDH1A1 monoclonal antibody, clone ALDH1A1/1381 (Cat # MAB14776).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human ALDH1A1.
Immunogen
Recombinant protein corresponding to amino acids 315-434 of human ALDH1A1.
Host
Mouse
Theoretical MW (kDa)
56
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Western Blot analysis of Lane 1: K562 and Lane 2: lung lysates with ALDH1A1 monoclonal antibody, clone ALDH1A1/1381 (Cat # MAB14776).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon carcinoma (A) and human testicular carcinoma (B) with ALDH1A1 monoclonal antibody, clone ALDH1A1/1381 (Cat # MAB14776).Immunofluorescence
Flow Cytometry
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Gene Info — ALDH1A1
Entrez GeneID
216Protein Accession#
P00352Gene Name
ALDH1A1
Gene Alias
ALDC, ALDH-E1, ALDH1, ALDH11, MGC2318, PUMB1, RALDH1
Gene Description
aldehyde dehydrogenase 1 family, member A1
Gene Ontology
HyperlinkGene Summary
This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a cytosolic isoform, which has a high affinity for aldehydes. [provided by RefSeq
Other Designations
ALDH class 1|acetaldehyde dehydrogenase 1|aldehyde dehydrogenase 1, soluble|aldehyde dehydrogenase 1A1|aldehyde dehydrogenase, liver cytosolic|retinal dehydrogenase 1|retinaldehyde dehydrogenase 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Comparison of quantum dot technology with conventional immunohistochemistry in examining aldehyde dehydrogenase 1A1 as a potential biomarker for lymph node metastasis of head and neck cancer.
Xu J, Müller S, Nannapaneni S, Pan L, Wang Y, Peng X, Wang D, Tighiouart M, Chen Z, Saba NF, Beitler JJ, Shin DM, Chen ZG.
European Journal of Cancer 2012 Jul; 48(11):1682.
Application：IF, IHC-P, WB-Tr, Human, A-549 cells, Human head and neck cancer.
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Comparison of quantum dot technology with conventional immunohistochemistry in examining aldehyde dehydrogenase 1A1 as a potential biomarker for lymph node metastasis of head and neck cancer.
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