TYMP monoclonal antibody, clone SPM322
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant human TYMP.
Immunogen
Recombinant protein corresponding to full length human TYMP.
Host
Mouse
Theoretical MW (kDa)
55
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
Immunoprecipitation (0.5-1 ug/500 ug protein lysate)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human placenta with TYMP monoclonal antibody, clone SPM322 (Cat # MAB14764).Immunoprecipitation
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Gene Info — TYMP
Entrez GeneID
1890Protein Accession#
P19971Gene Name
TYMP
Gene Alias
ECGF1, MNGIE, PDECGF, TP, hPD-ECGF
Gene Description
thymidine phosphorylase
Gene Ontology
HyperlinkGene Summary
This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000196768|OTTHUMP00000196769|endothelial cell growth factor 1 (platelet-derived)|gliostatin
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Interactome
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Pathway
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Disease
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Publication Reference
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Expression of the angiogenic factor thymidine phosphorylase/platelet-derived endothelial cell growth factor in primary bladder cancers.
O'Brien TS, Fox SB, Dickinson AJ, Turley H, Westwood M, Moghaddam A, Gatter KC, Bicknell R, Harris AL.
Cancer Research 1996 Oct; 56(20):4799.
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The angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase is up-regulated in breast cancer epithelium and endothelium.
Fox SB, Westwood M, Moghaddam A, Comley M, Turley H, Whitehouse RM, Bicknell R, Gatter KC, Harris AL.
British Journal of Cancer 1996 Feb; 73(3):275.
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Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: an immunohistochemical study.
Fox SB, Moghaddam A, Westwood M, Turley H, Bicknell R, Gatter KC, Harris AL.
The Journal of Pathology 1995 Jun; 176(2):183.
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Expression of the angiogenic factor thymidine phosphorylase/platelet-derived endothelial cell growth factor in primary bladder cancers.
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