DSG1 monoclonal antibody, clone 27B2
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human DSG1.
Immunogen
Recombinant protein corresponding to intracellular domain of human DSG1.
Host
Mouse
Theoretical MW (kDa)
150, 160
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunofluorescence
Flow Cytometry
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Gene Info — DSG1
Entrez GeneID
1828Protein Accession#
Q02413Gene Name
DSG1
Gene Alias
CDHF4, DG1, DSG
Gene Description
desmoglein 1
Gene Ontology
HyperlinkGene Summary
Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus. [provided by RefSeq
Other Designations
desmosomal glycoprotein 1|pemphigus foliaceus antigen
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Interactome
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Disease
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Publication Reference
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Desmoglein isotype expression in the hair follicle and its cysts correlates with type of keratinization and degree of differentiation.
Wu H, Stanley JR, Cotsarelis G.
The Journal of Investigative Dermatology 2003 Jun; 120(6):1052.
Application：IF, Human, Hair follicles.
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Generation of monoclonal antibodies specific for desmoglein family members.
Wahl JK 3rd.
Hybridoma and Hybridomics 2002 Feb; 21(1):37.
Application：IF, IP, WB-Tr, Human, A-431D cells.
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Desmoglein isotype expression in the hair follicle and its cysts correlates with type of keratinization and degree of differentiation.
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