CDX2 monoclonal antibody, clone CDX2/1690
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon cancer (A, B) with CDX2 monoclonal antibody, clone CDX2/1690 (Cat # MAB14722).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human CDX2.
Immunogen
Recombinant protein corresponding to amino acids 150-249 of human CDX2.
Host
Mouse
Theoretical MW (kDa)
40
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG2a, kappa
Recommend Usage
ELISA (2-4 ug/mL for coating)
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon cancer (A, B) with CDX2 monoclonal antibody, clone CDX2/1690 (Cat # MAB14722).Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
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Gene Info — CDX2
Entrez GeneID
1045Protein Accession#
Q99626Gene Name
CDX2
Gene Alias
CDX-3, CDX3
Gene Description
caudal type homeobox 2
Omim ID
600297Gene Ontology
HyperlinkGene Summary
The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear proteins that bind to specific sequences within the promoter of the insulin gene (INS; MIM 176730) and interact with RNA polymerase to activate or repress transcription. The proteins LMX1 (MIM 600298) and CDX3 are homeodomain proteins that bind an A/T-rich sequence in the insulin promoter and stimulate its transcription (German et al., 1994 [PubMed 7698771]).[supplied by OMIM
Other Designations
OTTHUMP00000018176|caudal type homeo box transcription factor 2|caudal type homeobox transcription factor 2
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Interactome
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Disease
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Publication Reference
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Cdx1 and cdx2 expression during intestinal development.
Silberg DG, Swain GP, Suh ER, Traber PG.
Gastroenterology 2000 Oct; 119(4):961.
Application：IHC-P, WB-Ce, WB-Tr, Mouse, ColoDM cells, Intestine, NIH/3T3 cells, Postnatal tissues.
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Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells.
Mallo GV, Soubeyran P, Lissitzky JC, André F, Farnarier C, Marvaldi J, Dagorn JC, Iovanna JL.
The Journal of Biological Chemistry 1998 May; 273(22):14030.
Application：WB-Ce, WB-Tr, Human, Colon cancer-derived cells, HT-29 cells.
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Cdx1 and cdx2 expression during intestinal development.
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